コデインそのものはμ-オピオイド受容体に弱い親和力を示す。主要な鎮痛作用はμ-オピオイド受容体へのモルヒネの親和性による。しかし他の作用または副作用は他のオピオイド受容体への作用による。
Narcotic analgesics may perhaps trigger nausea and vomiting by stimulating the chemoreceptor trigger zone (CTZ); nevertheless, they also depress the vomiting Heart, making sure that subsequent doses are unlikely to provide vomiting. Nausea is minimal after normal oral doses of codeine.
Moms that are extremely-speedy metabolizers of codeine accomplish better-than-anticipated serum amounts of morphine, potentially bringing about greater levels of morphine in breast milk that can be harmful to their breastfed infants.
Since recurrences of NMS have been claimed with phenothiazines, the reintroduction of promethazine HCl need to be meticulously regarded.
If you're taking promethazine/phenylephrine/codeine routinely in the course of pregnancy, your little one may have withdrawal signs or symptoms that could be daily life-threatening. Tell your healthcare service provider when you took promethazine/phenylephrine/codeine throughout your pregnancy, In particular near the conclude of your pregnancy.
For anyone who is employing a liquid kind of the medication, use a medication measuring system to carefully evaluate the prescribed dose. Tend not to utilize a residence spoon since you might not get the right dose. If you are using the suspension, shake the bottle properly before Every single dose.
This slight modification means that the molecule is topic to various metabolism than conventional testosterone.
There won't be any recognised interactions among promethazine/phenylephrine/codeine and foods or non-alcoholic beverages.
Bone-Marrow Despair – Promethazine needs to be utilised with warning in patients with bone-marrow depression. Leukopenia and agranulocytosis are reported, usually when promethazine HCl has actually been Employed in Affiliation with other known marrow-harmful agents.
FDA is warning about quite a few protection difficulties with prescription medicines that contains codeine used for soreness or cough and tramadol employed for discomfort: Codeine should not be employed to deal with agony or cough and tramadol really should not be used to deal with discomfort in little ones youthful than twelve years due to the potential risk of major Uncomfortable side effects, such as slowed or hard breathing and death.
As an opioid, codeine can result in Actual physical dependence and material use dysfunction in weeks of regular use.
You should definitely Adhere to the directions cautiously, due check here to the fact continuing constipation may result in far more critical difficulties.
Promethazine is contraindicated in comatose states, and in folks known to be hypersensitive or to own experienced an idiosyncratic reaction to promethazine or to other phenothiazines.
Bone marrow suppression may lead to infections or bleeding. This can be really serious or even lifestyle-threatening. Preserve all appointments to get your blood checked. Explain to your healthcare supplier instantly Should you have any of the subsequent signs or symptoms of bone marrow suppression.